Language

CAS No.1010085-13-8|MK-5108 (VX-689)

Name:MK-5108 (VX-689) CAS No.1010085-13-8 MF:C22H21ClFN3O3S MW:461.94 Purity:97% Package: 5mg,25mg,100mg,500mg,1g Worldwide Delivery

Categories：

Biochemicals

Email：sale06@alfachem.cn

Inquiry

Chat Now

Product introduction

Introduction and application of CAS No. 1010085-13-8 | MK-5108 (VX-689)

Synonyms:trans-4-(3-Chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]cyclohexanecarboxylicacid;

(1r,4r)-4-(3-chloro-2-fluorophenoxy)-1-((6-(thiazol-2-ylaMino)pyridin-2-yl)Methyl)cyclohexanecarboxylicacid;

Cyclohexanecarboxylicacid,4-(3-chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-,trans-;

Specification:

ITEMS	SPECIFICATION
CAS	1010085-13-8
MF	C22H21ClFN3O3S
MW	461.94
Boiling point	637.6±65.0 °C
Density	1.429
Acidity coefficient	4.41±0.44
Solubility	≥23.1 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
Form	Solid
Storage condition	under inert gas (nitrogen or Argon) at 2–8 °C

Biological activity:

MK-5108 (VX-689) is a highly selective AuroraA inhibitor with an IC50 of 0.064nM. Its selectivity for AchemicalbookuroraA is 220 and 190 times higher than that for AuroraB/C. It inhibits TrkA with a selectivity 100 times lower. Phase1.

Package and transportation :

Package: 5mg,25mg,100mg,500mg,1g